In 1990 study in San Diego, CA the dieting 5 active tablet subjects with allergic rhinitis had a lowered total serum IgE from Day 0 to Day 90 while 4 placebo subjects, (2 with allergic rhinitis, 1 with asthma and dieting 1 with both), had flat or increased IgE levels.4 In a randomized, double-blind, placebo controlled study of symptoms and serum IgE levels in San Diego, CA in mid-1991, subjects had allergic rhinitis and/or asthma. tablet Serum was drawn at Day 0 and Day 30. Seven of the 10 active treated subjects had a reduction in total serum dieting IgE levels. In 10 placebo treated subjects, 5 had levels of total serum IgE that stayed the tablet same (plus or minus 5%), 3 decreased and 2 increased.5 Statistical analysis of the open-label study as well as the double-blind randomized placebo controlled dieting study have shown a significant tablet effect of vitamin B12 in lowering serum IgE concentrations.

In 1992 in El Paso, TX a randomized, double-blind, placebo controlled study of subjects (n=130) with allergic dieting rhinitis in 1992-1993 was conducted. The average IgE tablet level of the placebo treated subjects remained essentially flat, while the average IgE dieting level for active treated subjects was reduced significantly from tablet baseline to Day 30.7 dieting In 1993 in El Paso, TX, valid subjects (n=66) returned a second set of symptom diaries which they had completed for days 365 to 395 (the same period, one year after the first set of symptom diaries). The active group had mean symptom scores showing statistically significant decreases from 1992 tablet to 1993. The placebo group had increased symptoms in 1993. (The relevant pollen counts at the study site in 1993 were much higher than in 1992, leading to expectation of higher symptoms.)7

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