In 1990 study in San Diego, CA the 5 active subjects with allergic rhinitis had a lowered total serum IgE from Day 0 to Day discount 90 while 4 placebo subjects, (2 with allergic vitamins rhinitis, 1 with asthma and 1 with both), had flat or increased IgE levels.4 In a randomized, discount double-blind, placebo controlled study of symptoms vitamins and serum IgE levels in San discount Diego, CA in mid-1991, subjects had allergic rhinitis and/or asthma. Serum was drawn at Day 0 and Day 30. Seven of the 10 active treated subjects had a reduction in total serum IgE levels. In 10 placebo treated subjects, 5 had levels of total serum IgE that stayed the same (plus or minus 5%), 3 decreased and 2 increased.5 Statistical analysis of the vitamins open-label study as well as the double-blind randomized placebo controlled study discount have shown a significant effect of vitamin B12 in lowering serum IgE concentrations.

With vitamins no further treatment, the 1996 ten-month discount follow-up data (n=92) from a high pollen period in Oregon, Washington and Idaho together vitamins showed a greater reduction in the active group (n=43) than the placebo group (n=49) on the primary endpoint, defined as a combination of symptom and rescue medication scores.8 Patients gave blood serum samples prior to the treatment in 1995 and one year later in 1996. They were immunoassayed for specific IgE antibodies using a chemi-luminescent technique. Statistician Bradley Rosebrook ran T-Tests comparing average baseline IgE levels to one-year. For the seasonal allergens reported, the active group (n=27) had on average a greater reduction in IgE than the placebo discount group vitamins (n=34) for 13 out of 16 allergens.8

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