In 1990 study in San Diego, CA the echinachea 5 active subjects with allergic rhinitis had herb a lowered total serum IgE from Day 0 to Day 90 while 4 placebo subjects, (2 with allergic rhinitis, 1 with asthma echinachea and 1 with both), had flat or increased IgE levels.4 In a randomized, double-blind, placebo controlled study of symptoms and serum IgE levels in San Diego, CA in mid-1991, subjects had allergic rhinitis herb and/or asthma. Serum was drawn at Day 0 and Day 30. Seven echinachea of the 10 active treated subjects had a reduction in total serum IgE levels. In 10 placebo treated subjects, 5 had levels of total serum IgE that stayed the same (plus or minus 5%), 3 decreased and 2 increased.5 Statistical analysis of the open-label study as well as the double-blind randomized placebo controlled study herb have shown a significant effect of vitamin B12 in lowering serum IgE concentrations.

In January echinachea 1997, 62 subjects who had been the placebos in the 1995 study herb were invited to receive the vitamin B12. In June 1997, the 62 placebo subjects were sent a questionnaire echinachea asking: How would you compare your overall herb allergy (hay fever) symptoms this spring to the last two springs? 20 people responded, with 15 reporting having had the B12 treatment, and 5 not. 12 of the 15 reported at least a slight improvement in overall allergy symptoms, and 1 of the 5. Improvement ratios - 12:3 having received treatment, 1:4 not having received treatment.8 echinachea A bioequivalence study showed that a 3000 mcg lozenge delivered an equivalent amount of cyanocobalamin to the blood as a 15 mcg injection.9 From the spring to the summer patients with demonstrated allergic rhinitis received with the cyanocobalamin (or placebo) containing lozenge herb twice daily for 21 consecutive days. All subjects also received C and B oral multivitamins for 21 days. Twice daily subjects maintained a nine-week diary on sneezing, runny nose, nasal congestion, itchy eyes, itchy nose and antihistamine (chlorpheniramine) use. In echinachea the post-treatment period, the active group (n=15) recorded on average a greater reduction in symptoms and in antihistamine use than the placebo group (n=9). The results yielded reductions (0.1>p>0.01) herb in total weekly echinachea symptom/rescue medication herb for the active group compared to the placebo for weeks 2, 6, echinachea 8 and 9. The results tend to replicate those of the studies on injectable cyanocobalamin.1 herb.

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